The Binding of Isaac challenges

All 18 The Binding of Isaac challenges, grouped into 3 categories. These are the same challenges the wheel spins from and the daily page picks from.

Character

Isaac Solo

Play Isaac. The D6 is allowed. Reroll at most once per item.
Magdalene Solo

Play Magdalene.
Cain Solo

Play Cain.
Lost rules Solo

Play The Lost if you have unlocked him. If not, play the Keeper or Isaac and you may not take red heart damage. A hit fails it.
No starting reroll Solo

Do not use a starting active item on the first room of a floor.
Co-op baby Any

Turn co-op on. The second player stays a baby and does not take a heart to become a full character unless the main player is about to die.

No devil Solo

Do not take devil deals.
No angel Solo

Do not take angel deals. You may still earn the room and leave it.
Treasure only Solo

Take item rooms and boss items. Skip shops, secret rooms, and challenge rooms.
One shop Solo

You may buy a single shop item on the run.
No pills Solo

Do not use pills.
Keys for doors Solo

Spend keys on the item room and the shop door only. Chests stay locked.

One floor pace Solo

Leave each floor within a few minutes of the boss dying. Do not full clear after the boss.
Boss rush skip Solo

If boss rush or the hush door opens, you do not take it. Go down.
Heart cap Solo

Do not pick up health ups that put you over four red hearts. Soul hearts are allowed.
Normal or hard Solo

Hard mode if you usually clear it. Otherwise normal. Do not switch mid run.
Mom clear Solo

Beat Mom. That is the end of the challenge. Cathedral and Sheol are optional and not required.
Both alive Any

In co-op, both players are alive when Mom dies.